Protein type:DNA-binding Oncoprotein Transcription factor Nuclear receptorĬhromosomal Location of Human Ortholog: 17q21Ĭellular Component: nucleoplasm cell surface cell soma perinuclear region of cytoplasm cytoplasm dendrite nuclear chromatin nucleus actin cytoskeleton Two splice-variant isoforms have been described. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Its phosphorylation is crucial for transcriptional activity. Controls cell function by directly regulating gene expression. RARA is a member of the nuclear receptor superfamily. RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development.
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March 2023
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